WebApr 10, 2024 · Reduced cortical inhibition by somatostatin-expressing (SST) interneurons has been strongly associated with treatment-resistant depression. However, due to technical limitations it is impossible to establish experimentally in humans whether the effects of reduced SST interneuron inhibition on microcircuit activity have signatures … Web偏頭痛病生理機轉. 陳世彬. 台北榮民總醫院神經內科. 偏頭痛 (migraine)是全世界最常見且最令人失能神經科疾病,不論對個人、醫療體系、或是社會經濟層面的影響都有相當大的 …
Cortical Spreading Depression in the Setting of ... - ScienceDirect
WebSep 21, 2024 · Abstract. Cortical spreading depression (CSD), a wave of depolarization followed by depression of cortical activity, is a pathophysiological process implicated in migraine with aura and various other brain pathologies, such as ischemic stroke and traumatic brain injury. To gain insight into the pathophysiology of CSD, we generated a … WebNov 3, 2010 · Introduction. Cortical spreading depression (CSD) is a depolarization wave in cerebral gray matter that propagates across the brain at slow velocity, 2 to 5 mm/min ().In normal brain tissue studied experimentally, CSD usually has to be induced by a deliberate perturbation of the brain such as electrical or mechanical stimulation ().The CSD silences … route 66 mapping
Frontiers Understanding Spreading Depression from …
WebJul 20, 2016 · Cortical spreading depression (CSD) is involved in various neurological diseases such as migraine, stroke, subarachnoid hemorrhage, and traumatic brain injury. 1,2 In migraine, CSD is the likely mechanism underlying the migraine aura, 3 and, in animals, was shown to activate headache mechanisms. 4 CSD is characterized as a … WebMar 4, 2024 · Cortical spreading depolarization (CSD) is a massive neuro-glial depolarization wave, which propagates across the cerebral cortex. In stroke, CSD is a necessary and ubiquitous mechanism for the development of neuronal lesions that initiates in the ischemic core and propagates through the penumbra extending the tissue injury. WebFeb 1, 2024 · Cortical spreading depression (CSD) is a pathophysiologic phenomenon that describes an expanding wave of depolarization within the cortical gray matter. … route 66 maps navigation full