WebBackground: The phase 3 JAVELIN Renal 101 trial (NCT02684006) demonstrated significantly improved progression-free survival (PFS) with first-line avelumab plus axitinib versus sunitinib in advanced renal cell carcinoma (aRCC).We report updated efficacy data from the second interim analysis. Patients and methods: Treatment-naive patients with … Web18 set 2024 · Patient Population. In the JAVELIN Bladder 100 trial, we enrolled patients who had histologically confirmed, unresectable locally advanced or metastatic urothelial … Perspective. Ensuring Public Trust in an Empowered FDA J.S. Ross, K.M. Berg, … Explore a collection of articles and other resources on the Coronavirus (Covid … The cardiology hub contains articles on heart disease, coronary disease, … The oncology and hematology hub contains articles on breast cancer, lung cancer, … Original Article from The New England Journal of Medicine — Pembrolizumab … Image Challenge from the New England Journal of Medicine — April 13, 2024 Non è possibile visualizzare una descrizione perché il sito non lo consente.
Efficacy and safety of first-line avelumab in patients with advanced ...
Web24 ott 2024 · Antibodies targeting programmed death-1 (PD-1) or programmed death-ligand 1 (PD-L1) have shown clinical activity in the treatment of metastatic renal cell carcinoma (mRCC). This phase Ib cohort of the JAVELIN Solid Tumor trial assessed the efficacy and safety of avelumab (anti–PD-L1) monotherapy in patients with mRCC as either first-line … WebAvelumab is a human anti-PD-L1 checkpoint inhibitor with clinical activity in multiple solid tumors. Here, we describe the rationale and design for JAVELIN Ovarian 200 (NCT02580058), the first randomized Phase III trial to evaluate the role of checkpoint inhibition in women with ovarian cancer.This three-arm trial is comparing avelumab … fuel injected cruiser motorcycle
Avelumab Maintenance Therapy for Advanced or …
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